In last years, advances in the field of neurodegenerative disorders have pointed an association between diet, gut microbiota and disease progression, leading to the emergence of the gut-microbiome-brain axis. Inspired by the importance of diet and microbiota on organism physiology, the aim of this project is to understand host-microbiota interrelations and to elucidate how microbiota is able to affect homeostasis and modulate progression of neurodegenerative disorders in C. elegans.